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KO of the efflux pump ABCC1 significantly sensitized cells to arsenic and mercury compared with the control cell line bearing the sgRNA targeting the unrelated gene olfactory receptor 1A1 ( OR1A1 ) (Fig 3A and B)

Protocol: Daily topical application as above

The precursor chemical Nle1-angiotensin IV was used to create this tiny molecule

& Yong, V

A large trial reported in 1994 (pdf) that daily megadoses of the antioxidant beta-carotene increased the risk of lung cancer in male smokers by 18 percent and a 1996 trial was stopped early after researchers discovered that high-dose beta-carotene and retinol, another form of vitamin A, increased lung cancer risk by 28 percent in smokers and workers exposed to asbestos

PMID: 12668217