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The PEG corona in these nanocomposites reduces nonspecific cellular uptake by normal tissues through steric hindrance and surface charge modulation, as evidenced by flow cytometry showing 2.3-fold higher tumor cell internalization compared to non-targeted counterparts

doi:10.1038/nchembio.499

Glutathione is a sulfur-containing peptide made up of three amino acids: glutamic acid, cysteine and glycine

AKR-001, an Fc-FGF21 analog, showed sustained pharmacodynamic effects on insulin sensitivity and lipid metabolism in type 2 diabetes patients

Side effects of taking Melanotan II nasally include nausea, dizziness, darkening of moles, serious allergic reaction such as anaphylaxis, facial flushing, changes in appetite, and sexual side effects like increased erections due to the hormone used

In trials for MASH, survodutide demonstrated significant reduction in liver fat and improvement in liver fibrosis scores