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Answer: Beyond life circumstances, the common biological drivers are imbalances in serotonin, dopamine, and GABA, shifts in estrogen, progesterone, and testosterone, a disrupted cortisol rhythm, and underlying issues like thyroid dysfunction, adrenal strain, or systemic inflammation

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Otherwise, bile duct-ligated rats commonly presented intracranial (superior sagittal sinus), portal and caval hypertension and aortal hypotension, gross brain swelling, hemorrhage and lesions, heart dysfunction, lung lesions, liver and kidney failure, gastrointestinal lesions, and severe arterial and venous thrombosis, peripherally and centrally

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