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In this review, we will focus on the metabolic effects of IGF-1, the concept of metabolic syndrome and its clinical manifestations (impaired lipid profile, insulin resistance, increased glucose levels, obesity, and cardiovascular disease), discussing whether IGF-1 replacement therapy could be a beneficial strategy for these patients

P.da Silva GesteiraA.MicheliF.et al

J Investig Dermatol Symp Proc

Pregnant or Breastfeeding Women: They require higher levels to support the growing baby

The oxidative pathway produces N-acetyl-p-benzoquinone imine (NAPQI), a highly reactive metabolite capable of binding cellular proteins and causing hepatocyte death

Zimmermann R et al