Last reviewed: May 12, 2026 Last updated: May 12, 2026 Written by: Jay Hastings , CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations
It is used in combination with GLP-1 in the weight-loss medications Zepbound (US) and Mounjaro (UK) - known as dual GIP/GLP-1 receptor agonists
The most frequently reported symptoms included: Nausea (the most common, with rates varying by dose readers should refer to the published trial data and supplementary tables for dose-specific figures) Vomiting Diarrhoea Constipation Upper abdominal pain or discomfort Decreased appetite These effects are largely attributable to the drug's action on GLP-1 receptors in the gastrointestinal tract, which slow gastric motility and alter gut hormone signalling
Some patients notice appetite suppression within the first few days
They need to be metabolized to work, Dr
Never adjust your dose on your own, as proper titration is essential for both safety and effectiveness
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