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2025 Impact of transfusion dependent alpha- and beta-thalassemia on adult patients health-related quality of life and work productivity: A multi-region real-world survey Janet Kwiatkowski 1 , Khaled Musallam 2 , Maria Domenica Cappellini 3 , Christina Chamberlain 4 , Amey Rane 4 , Keely Gilroy 4 , Susan Morris 4 , Emma Chatterton 5 , Brianne Kerr 5 , Katie Lewis 5 , Ali Taher 6 1 Childrens Hospital of Philadelphia, Philadelphia, Pennsylvania, USA, 2 Burjeel Medical City, Abu Dhabi, United Arab Emirates, 3 Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy, 4 Agios Pharmaceuticals, Cambridge, Massachusetts, USA, 5 Adelphi Real World, Bollington, UK, 6 American University of Beirut Medical Centre, Beirut, Lebanon Journal of Patient-Reported Outcomes 2026 , 10(Suppl 1) :2025 Aims Research on the impact of transfusion-dependent thalassemia (TDT) on health-related quality of life (HRQoL) and work productivity is limited, particularly in -TDT
Notably, once a patient transitions to combination injectable therapy, the ADA recommends the addition of a GLP-1 receptor agonist for patients who require improved postprandial glycemic control despite basal insulin optimization
A personalized plan and professional support are key not just for weight loss but for your overall recovery and wellness journey
The starting dose used in phase 2 clinical trials has been low, with a gradual, pre-specified dose-escalation schedule over subsequent weeks to improve tolerability
Yes, GI effects are common
However, people should contact a health care provider right away if they experience any of the following: Difficulty swallowing or breathing Intense pain or tenderness in the belly Jaundice (yellow skin or eye color) Mass in the neck Persistent hoarseness Severe vomiting or diarrhea Vision changes Key takeaways Some GLP-1 medications help control blood sugar, and others aid in weight loss
