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We used our model to study the effect of increased activity of the P450 enzymes on the level of NAPQI covalent binding and the predicted associated level of hepatic cell necrosis

European Association for the Study of Obesity (EASO)

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Consistently, the livers of HFD-fed mice showed increased IKK--SSG levels, decreased IKK- phosphorylation, and suppressed NF-B activation when compared to these from control animals

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Moreover, GHK upregulated the level of miR-146a-3p and decreased the expression of AQP4, while the LY294002 and MK-2206 2HCL could reverse these effects