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2.2 Animals Thirty-two male BALB/c mice, aged 68 weeks and weighing 1822 g, were provided by Jinan Pengyue Experimental Animal Breeding Co., Ltd

Additional SAGE-DM mechanisms, which may be considered as second-level modifiers or hypotheses rather than SAGE-DM hallmarks, include: cellular senescence-associated tissue dysfunction, immune remodeling with adipose tissue accumulation of regulatory T-cells, altered FGFR1 signaling, and the potential action of senescence-targeting agents

In patients, the degree of atrial fibrosis correlates with the occurrence of postoperative AF as well as with the persistence and recurrence of AF [126, 127]