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InsR/IGF1R pathway mediates resistance to EGFR inhibitors in glioblastoma
In this process, reduced L-glutathione (also known as GSH) is transformed into its oxidized form (GSSG)
Nf2 pathways Heme oxygenase 1 (HO-1), a downstream protein of the Nrf2 pathway, contributes to anti-inflammatory and antiviral responses, removes toxic heme, protects against oxidative injury and also regulates apoptosis, inflammation and angiogenesis (Espinoza et al., 2017)
[PubMed] Smith BM, Schwartzman K, Kovacina B, et al
Cureus, 16(11), e73350.
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