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A second pathway, ERK1/2 signalling, governs cell survival and fibroblast activity, and appears especially relevant in tissue thats naturally poor in blood supply, tendons and ligament junctions being the clearest examples (Rodgers et al., 2025)

An evaluation of pegvisomant as long-term monotherapy in acromegalic patients from the global safety surveillance study ACROSTUDY reported increases or increases/decreases in the tumor sizes in 12 of 542 subjects (2.2%)

doi: 10.1080/21691401.2019.1607362 196 QuSPLiGWMaHXingQ

Studies in mice show that HGF and MET expression is detectable in the brain during early embryonic growth at E12 and E13, respectively (Jung et al., 1994

Moller L, Dalman L, Norrelund H, Billestrup N, Frystyk J, Moller N, et al

See the 2025 BPC-157 literature and patent review by Jzwiak and colleagues in Pharmaceuticals (Basel) for the underlying chemistry