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Glutaminolysis Pathway: As discussed, glutamine is converted to glutamate by glutaminase (GLS), which is then deaminated by glutamate dehydrogenase (GDH) to form -KG

Experimental investigations have demonstrated that Dihexa modulates HGF-associated signaling pathways involved in cellular communication, synaptic regulatory mechanisms, and receptor-mediated signal transduction

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However, clinical trials of molecular hydrogen in fibromyalgia remain lacking, and well-controlled clinical studies are needed to confirm efficacy, optimal dosing, and safety (39)