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Description

Comprehending this mechanism provides insight into the origin of these symptoms

PMID 36397928

To this end, further work is needed to address whether increasing alpha-cell PC1/3 expression can shift alpha-cell proglucagon processing to favor GLP-1 production over glucagon, thereby mitigating the metabolic consequences of hyperglucagonemia

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J Coll Physicians Surg Pak

Gene-expression regulated by epigenetic modifications, such as alter DNA accessibility and chromatin structure, histone modification, and DNA methylation 1,2