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Development of auto-antibodies Some cobalamin preparations in rare cases can stimulate an allergenic response where there is development of antibodies to the cobalmin injected
Antioxidants, 9(5), 425
The 2% and 5% topical formulations require no prescription, though higher concentrations or oral formulations fall under different regulatory categories
Storage Of Reconstituted Drug Product Once reconstituted, hydroxocobalamin is stable for up to 6 hours at temperatures not exceeding 40C (104F)
Mechanistic tool in preclinical work: Used to explore lipid and glucose metabolism pathways in controlled models of energy balance
Standard clinical escalation protocol The Phase 2 trial published in the New England Journal of Medicine established the titration schedule that most researchers follow
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