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discovered that knocking down hyaluronidase-1 in mice with LPS-induced sepsis significantly alleviates kidney inflammation, oxidative stress, apoptosis, and renal dysfunction in AKI (140)

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Dual GLP1 and GIP agonists Tirzepatide is a once weekly, subcutaneous, unimolecular dual RA (GLP-1 and GIP) which has comparable GIP receptor binding affinity to native GIP and 5 times lower GLP-1 receptor affinity than that of native GLP-1