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Mediated by the TOM complex, PINK1 undergoes trans-autophosphorylation and subsequent conformational rearrangement, thereby activating the E3 ubiquitin ligase activity of Parkin through its transition from an autoinhibited state to an active conformation (Riley et al., 2013)

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Ion pairs with various isotope labels were derived based on the precursors and fragments chemical structures and molecular weights