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GLP-1 hormones play a crucial role in regulating blood sugar levels, insulin secretion, and appetite

The gut microbiome, kidney disease, and targeted interventions

This is also supported by the fact that besides KIT and PTEN , mutations in PI3K and AKT homologous of PI3K-AKT-mTOR are scarce (4.8% PIK3CA , 3.8% PIK3CG , and 4.8% AKT3 ) ( 105)

Based on these findings, inhibiting GSK3 could be a novel therapeutic strategy for the treatment of patients with T2DM, not only by enhancing insulin sensitivity, but also by improving insulin secretion

Patients with certain conditions may require modified protocols or alternative treatments entirely

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