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Tissue-specific expression of the human receptor for glucagon-like peptide-I: brain, heart and pancreatic forms have the same deduced amino acid sequences

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7 While resmetirom and semaglutide exert their anti-fibrotic effects primarily through metabolic improvements, FGF-21 analogues offer a dual mechanism, combining metabolic improvements with a direct anti-fibrotic effect via hepatic stellate cells (HSC)/macrophage pathways