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Without adequate GSH to replenish NADPH, low NADPH levels result directly in increased ROS which can damage mitochondria, DNA, and other important cellular components [24,25]

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UPR is associated with three ER transmembrane receptors: protein kinase R-like endoplasmic reticulum kinase (PERK), activating transcription factor 6 (ATF6) and inositol-requiring kinase 1 (lRE1) in mammalian cells (Szegezdi et al., 2006)

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