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In a phase 2 trial in participants with obesity and MASLD, once-weekly treatment with the GIP/GLP-1/GCG triple agonist retatrutide resulted in substantial reductions in liver fat, body weight, abdominal visceral adipose tissue (VAT) and abdominal subcutaneous adipose tissue (ASAT), serum lipids

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Targeted depletion of these macrophage subsets effectively prevented the development of injury-induced chronic pain, highlighting their critical role in pain pathogenesis (208)