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Chronic inflammation, oxidative stress, and ferroptosis are thought to induce chondrocytes to excessively generate catabolic factors, resulting in the degradation of chondrocytes and ECM, hence accelerating the degeneration of articular cartilage in OA [41-46]

Wang N, Zhang L, Lu Y, Zhang M, Zhang Z, Wang K, et al

[DOI] [PubMed] [Google Scholar] 98.Powrie JK, Bassett EE, Rosen T, Jorgensen JO, Napoli R, Sacca L, Christiansen JS, Bengtsson BA, Sonksen PH

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Many researchers report visible improvements even during weeks when the scale remains stable