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Oxidant-antioxidant imbalance is seen in females suffering from PCOS, and this oxidative stress is due to various metabolic abnormalities such as obesity, hyperinsulinemia, and dyslipidemia [11]

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Eric Topol (30:55): Well, what's interesting is we're pretty close friends, and he, not only that paper you mentioned on organ clocks, which is a phenomenal contribution, but he has a paper coming out soon in Nature Medicine, the preprint is up, and what he showed was that the brain and the immune system was the main organ clocks that were associated with longevity