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Actually, in the 1950s, many people with a diagnosis of pernicious anaemia were treated with high doses of folate, as B12 injections were not yet available

DAmario D, Rodolico D, Cappannoli L, Migliaro S, Crea F

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Recent advances in the knowledge of cancer biology led to the development of a new diagnostic and therapeutic arsenal that is not limited to selective target drugs but also includes already existing drugs that are multi-targeted or used in polypharmacology (Gonzalez-Fierro and Dueas-Gonzlez, 2021)

Diabetes Obes Metab 26(8):31283136