Untangling determinants of enhanced health and lifespan through a multi-omics approach in mice
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Notably, three differentially expressed genes (HMGB1, CP, TF), at the single-cell level, encode secreted proteins which may impact the susceptibility of dopaminergic neurons in the SN of PD patients to ferroptosis
Singh et al, 2021), Genes common among published target sets include those related to redox biology (i.e., GCLC , SLC7A11 , TXN ) and the pentose-phosphate pathway (PPP, i.e., PGD , TALDO1 ), in addition to many NADP-dependent metabolic enzymes (i.e., AKR1C1 , AKR1B10 , and CYP4F11 )
doi: 10.1016/j.bbr.2019.02.031 102 NadlerV.KainicJ
Sermorelin therapy overview.