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in: PubMed | Google Scholar | Published December 22, 2022 - More info Insulin and IGF-1 receptors (IR and IGF1R) are highly homologous and share similar signaling systems, but each has a unique physiological role, with IR primarily regulating metabolic homeostasis and IGF1R regulating mitogenic control and growth

Administration of IGF-I down-regulates proteolysis but does not appear to alter protein synthesis (Hussain, Schmitz, Mengel et al., 1994)

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