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For patients with Hashimoto's, this genetic variation is particularly valuable because lower effective doses may reduce the metabolic stress and thyroid hormone fluctuations associated with rapid weight loss

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Biomed Pap 160(4):461466

The table gives four to eight weeks for glucose impact in controlled type 2 diabetes alongside a 0.5 to 1.5 point HbA1c reduction, and six to 12 weeks for optimal response in uncontrolled diabetes with a 1 to 2 point reduction