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Ecological momentary assessment and cue-elicited drug craving as primary endpoints: study protocol for arandomized, double-blind, placebo-controlled clinical trial testing the efficacy of a GLP-1 receptor agonist in opioid use disorder

The biological activity can be assessed using a colorimetric bioassay consisting of the engineered cell line HEK-Blue GLP-1 expressing the GLP-1R together with a CREB-inducible SEAP reporter gene (see figure)

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For some patients, this may be 5-6 months, while others may need more time to get where they need to be and feel confident in sustaining their results without their injections

Recommended dose: 1 capsule per day to complete a main meal

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