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Therapeutic Modulation of Virus-Induced Oxidative Stress via the Nrf2-Dependent Antioxidative Pathway

This approach delivers superior weight loss velocity compared to single agents in clinical trials while maintaining the same fixed monthly cost

doi:10.1056/NEJMoa2032183 Jastreboff AM, et al

Guanylate Cyclase-C Agonists Examples: Linaclotide, Plecanatide Mechanism: cGMP activates CFTR channels intestinal fluid secretion accelerate transit Uses: Chronic constipation, IBS-C Adverse Effects: Diarrhea, abdominal pain Bulk-forming safest, long-term use Osmotic acute or hepatic encephalopathy (lactulose) Stimulants short-term only Stool softeners post-surgery, hemorrhoids Lubricants avoid long-term Chloride channel activators & GC-C agonists newer agents for chronic constipation Mnemonic for Laxatives: BOSS-LC B Bulk-forming O Osmotic S Stimulant S Stool softeners L Lubricant C Chloride channel activators / cGMP agonists To view or add a comment, sign in Sodium bicarbonate (NaHCO) is a systemic alkalinizing agent used to correct metabolic acidosis and as a source of bicarbonate ions in various clinical situations

However, the company has also received a few negative reviews during this period

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