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Liposomal technology struggles with technical challenges involving water-soluble compounds like NAD+

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The tert-butyl moiety of compound 2 points to TM7 and makes hydrophobic contacts with A350 6.39b and K351 6.40b , replacement at the C-3 position by polar functional groups caused a dramatic decline in its potency and efficacy 38

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There have been extensive animal-based studies conducted on the functioning of IGF-1 in the body