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Alveolar macrophages derived from circulating monocytes recruited into the lungs by monocyte chemotactic factors produced by lung cells are increased 20-fold in COPD patients and release ROS as superoxide anions and hydrogen peroxide (102)

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They also looked for issues that negatively affected the health of the fetus, including preterm birth (before 37 weeks), major birth defects (including of the kidneys, heart, and nervous system), stillbirth, and abnormal birth weight (both small and large)