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Most cases were mild to moderate and clustered during the dose-escalation period

Some people report a noticeable return of appetite or reduced efficacy in the final day or two before their next scheduled dose

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Enteric nervous system The ENS is an independently functioning neural system innervating the entire GI tract and containing two bundles of ganglia: one underneath the epithelial layer of the gut (submucosal plexus) and the other between the smooth muscle layers of the gut (myenteric plexus) 25