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It was found that approximately 10% of BA patients showed serum CMV IgM+, and CMV IgM + BA patients usually have a worse outcome with reduced clearance of jaundice, native liver survival, and increased mortality, representing a distinct clinical and pathological entity of BA with a diminished response to KPE ( In mammals, DNA methyltransferases (DNMTs), such as DNMT1, DNMT3A, and DNMT3B, write and regulate the DNA methylation patterns, which in turn regulate gene expression