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Anthracycline-induced toxicity in this trial did not appear to be worsened by combination with VPA, and other toxicities are manageable providing some reassurance that any synergy in terms of efficacy will not be replicated in unwanted side effects

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The authors suggested that the lack of VIP-mediated gland secretion might promote a hyper-inflammatory airway environment that contributes to CF lung disease

Cesta, C