Maintaining dietary modifications and physical activity established during treatment can help mitigate weight regain
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When compared with placebo or other therapies, GLP-1 agonists were associated with an increased risk of biliary disease [23]: Overall biliary disease: RR 1.37(95% CI 1.231.52) Cholelithiasis: RR 1.27 (95% CI 1.101.47) Cholecystitis: RR 1.36 (95% CI 1.141.62) Mechanisms: Reduced gallbladder motility Rapid weight loss increased cholesterol saturation and gallstone formation
We dont know effects of 5-year or 10-year use because trials havent run that long yet
[DOI] [PubMed] [Google Scholar] 158.Modestino E.J., Bowirrat A., Baron D., Thanos P.K., Hanna C., Bagchi D., Braverman E.R., Dennen C.A., Badgaiyan R.D., Pollack A.R., et al