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Obesity 28 , 122131 (2020)

Several mutations in the melanocortin-4 receptor gene including a nonsense and a frameshift mutation associated with dominantly inherited obesity in humans

Since baseline collagen production is known to decline roughly 1% per year starting in the mid-20s, a compound that reactivates a suppressed signaling pathway rather than simply adding raw material is mechanistically interesting in a way that most topical actives aren't

Follow-up cadence is established (virtual check-ins and messaging), and the clinician monitors side effects, weight trends, and necessary labs

Dietary adjustments may help alleviate these symptoms

February 17, 2026