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For most adults with newly diagnosed type 2 diabetes without cardiorenal disease, metformin plus lifestyle modification remains initial therapy, with GLP-1 agonists as preferred second-line agents

In cases of estrogen dominance, phytoestrogens can bind to estrogen receptors, displacing estrogen and causing a lower estrogenic response

Current clinical trials evaluating the safety and efficacy of these peptides will provide valuable insights into their potential use in clinical practice (187,188,189)

MomcilovicDReznakovaBBosseFBegrichCBernhardtCHamikoMet al