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Tirzepatide, a dual-agonist peptide, has shown significant results with a 22.5% weight loss over 72 weeks at a 15 mg dose (Jastreboff et al., NEJM), making it one of the most effective therapies for obesity

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Based on the UK Biobank data, genetic prediction of vitamin B12 concentrations showed no association with liver enzymes in the main analysis (IVW-multiplicative random effects)

We appreciate a commenter's position that there are existing CMS programs that drive patient safety improvement and that additional efforts may be conflicting, but we respectfully disagree and believe that further emphasis of patient safety in the Overall Hospital Quality Star Rating aligns with other efforts to improve patient safety including through HACRP

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