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Metformin continues to be the first-line recommended therapy for almost all patients with type 2 diabetes The selection of medication added to metformin is based on patient preference and clinical characteristics, including presence of cardiovascular disease, heart failure and kidney disease

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Hypoglycemic substances, like caffeine, should be avoided

Nat Clin Pract Cardiovasc Med 6(1):1626 Deedwania PC (2004) Diabetes is a vascular disease: the role of endothelial dysfunction in pathophysiology of cardiovascular disease in diabetes