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Suppression of cytosolic NADPH pool by thionicotinamide increases oxidative stress and synergizes with chemotherapy
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In total, 31 adults with T2DM and fibrosis due to MASH (F1-F3) on treatment with a stable GLP-1RA (semaglutide 48.4%, dulaglutide 45.2%, and liraglutide 6.5%) received efruxifermin 50 mg (n = 21) or placebo (n = 10) for 12 weeks
The inflammatory microenvironment in active IBD can markedly upregulate HIF-2 in colonic tissues ( Finally, ferroptosis itself can reinforce HIF activation and disease progression
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