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Synthesis 54 , 35583567 (2022)
Benkhoucha M, Molnarfi N, Kaya G, Belnoue E, Bjarnadttir K, Dietrich P-Y, Walker PR, Martinvalet D, Derouazi M, Lalive PH
YXH2024YS039), and Research Fund of Qianfoshan Hospital (grant no
The discovery that gut microbial metabolism of L -carnitine involves a second quantitatively significant sequential pathway for TMA formation from distinct microbial taxa suggests numerous targets are at hand if one wishes to pharmacologically manipulate the catabolism of carnitine into TMA/TMAO for potential treatment or prevention of CVD, such as through shifting of gut bacterial composition (probiotic, prebiotic) or inhibition of bacterial enzymatic activities
[3] Frias JP, et al
It was found that approximately 10% of BA patients showed serum CMV IgM+, and CMV IgM + BA patients usually have a worse outcome with reduced clearance of jaundice, native liver survival, and increased mortality, representing a distinct clinical and pathological entity of BA with a diminished response to KPE ( In mammals, DNA methyltransferases (DNMTs), such as DNMT1, DNMT3A, and DNMT3B, write and regulate the DNA methylation patterns, which in turn regulate gene expression
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