Thats likely due to the fact that, pound for pound, extra weight has an outsize effect on joints
Your tolerance is different than before medication, and you may be more impaired than you realize
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Generally, you will start to see improvements within two weeks, usually in terms of vomiting and/or diarrhea frequency
Gaining extra weight can make insulin resistance worse and lead to more severe symptoms
For example, it is not clear whether intestinal microbiota can form SFN conjugates such as SFN-GSH or SFN-NAC