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Low immunogenicity of LNP allows repeated administrations of CRISPR-Cas9 mRNA into skeletal muscle in mice

The concern isnt just that youll develop antibodies against the peptide itselfits that those antibodies might cross-react with your own endogenous proteins

They are different molecules with different mechanisms, different efficacy profiles, and different regulatory statuses

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Stack two that work on different systems and you cover more ground without piling on side effects from the same receptor getting hit twice

(5) Standard viability assays, including those that quantify cell density and metabolic activity, indicated that tested cultures supported higher fibroblast numbers compared to controls