Toxic lipid peroxides can be converted into nontoxic lipid alcohols (L-OH) in the presence of GPX4 and GSH to inhibit ferroptosis [21]
However, studies with transfected Chinese hamster ovary cells suggest that the type-2 isozyme may actually have a neutral pH optimum in its native state, and that the acidic optimum described may actually be an artifact of cell lysis 15
277 Scavenger receptor class B type I (SRBI) plays a crucial role in promoting cholesterol efflux from cells and clearing plasma cholesterol, while SRBI deficiency results in disrupted cholesterol metabolism, hyperlipidemia, and subsequent ferroptosis via the HIF-1/TFR1 pathway
Pramlintide reaches peak serum levels within 30 min of administration and has linear pharmacokinetics
At present, relevant studies have confirmed that the expression of ALOX12 can reasonably predict the prognosis of patients, and ALOX12 can be used as a predictor of tumor prognosis [36,37,38]