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22,23 In essence, restricting the consumption of animal protein to maintain a relativelybut not excessivelylow IGF-1 is an important objective for optimal aging

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7.4.2 Pharmacological agents for neuroinflammation Neuroinflammation, characterized by the activation of microglia, astrocytes, and the release of pro-inflammatory cytokines, is a major contributor to cognitive dysfunction and BBB breakdown following intestinal I/R injury (Ronaldson and Davis, 2020)

Those are the high-impact variables