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iScience 26 (10), 107909

Without NAD+ there is no ATP

2016 Nov;42(5):31627

In general, older adults often need lower doses of CNS-active compounds due to changes in metabolism, body composition, and tissue sensitivity

While the cause of ME/CFS is unknown, many factors are through to contribute to the development of the illness, such as: (1) bacterial or viral infections, or (2) physical or emotional trauma, including from an accident, concussion, immobilization, surgery, trauma, or even a significant emotional stress such as loss of a loved one

(PubMed) Salinthone S, Schillace RV, Marracci GH, Bourdette DN, Carr DW