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doi: 10.1016/j.tcb.2022.02.009 50 ZhuJBerisaMSchworerSQinWCrossJRThompsonCB

Safety Considerations and NHS Guidance on Berberine Whilst berberine appears generally well-tolerated in short-term studies (often using doses of 500 mg two to three times daily), several important safety considerations warrant attention

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Patients often begin losing weight within 46 weeks , with steady progress thereafter