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Molecular chaperones such as mtHsp60, mtHsp70, and mtDnaJ are the main proteins involved in the UPR mt [51]

The supernatant was collected, adjusted to pH 4.5 using 2.5 M HCl and stored at 4 C for 12 h to facilitate protein precipitation

1ip and Extended Data Fig

Journal of Diabetes Research and Clinical Metabolism

The development of SGLT2 inhibitors and GLP-1RAs has reshaped the therapeutic landscape, demonstrating robust and glycemia-independent renoprotective benefits (Tomita et al., 2020)

In a methicillin-resistant Staphylococcus aureus (MRSA) infection model, mice treated with spermidine exhibited significantly improved survival rates and enhanced bacterial clearance, providing robust experimental evidence for spermidines potential application in treating infectious diseases and laying the groundwork for its clinical use as an immunomodulator (116)