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ANIMAL Sci

When compared with placebo or other therapies, GLP-1 agonists were associated with an increased risk of biliary disease [23]: Overall biliary disease: RR 1.37(95% CI 1.231.52) Cholelithiasis: RR 1.27 (95% CI 1.101.47) Cholecystitis: RR 1.36 (95% CI 1.141.62) Mechanisms: Reduced gallbladder motility Rapid weight loss increased cholesterol saturation and gallstone formation

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So, when dosing for type 2 diabetes, the goal is to give the lowest possible dose to get the glycemic management desired and to MINIMIZE those side effects

There is baseline secretion of GLP-1 even during fasting (510 pm), but postprandially induced production increases with meal size (1030 pm)

This has prompted a different kind of concern: whether lower-priced Canadian semaglutide could leak into the US through grey or illicit channels while American patents remain intact well into the 2030s