Targeting hypoxia: hypoxia-activated prodrugs in cancer therapy
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The reduction by dutasteride of prostate cancer events (REDUCE) trial is another multicenter, randomized, international, placebocontrolled, double blind clinical trial initiated in 2003 to evaluate the ability of dutasteride to decrease the risk of biopsy detectable prostate cancer in men with moderately elevated PSA levels
Interestingly, most mutations in translation pathways such as mTOR, ERK, and FMRP-eIF4E-CYFIP lead to abnormally high levels of synaptic translation and synaptic proteins
Gwyer D, Wragg NM, Wilson SL (2019)
Sunitinib malate for the treatment of pancreatic neuroendocrine tumors