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Given that HD affects different regions of the brain, its typical clinical manifestations include motor and cognitive disorders, as well as mental and behavioral abnormalities

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Nrf2 activation leads to the upregulation of detoxifying enzymes that neutralize reactive aldehydes like 4-HNE, thereby reducing their inhibitory effects on pathways such as PI3K/AKT/mTOR and Wnt/-catenin [134]

We have complete a Phase 1B study with promising safety and efficacy results and are preparing for a Phase 2B trial

It has been found that mutation in ZnT8 may contribute to dysregulation in insulin in the first passage through the liver and increase risk of type 2 diabetes mellitus development [136]