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Reports from the FDA have linked medications like exenatide to altered kidney function, particularly in patients with additional risk factors such as nephrotoxic drugs and hypertension

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(48) did not support the existence of this proximal-distal incretin loop in humans as intravenous injection of GIP into humans did not enhance GLP-1 secretion, pointing to the fact that the animal models may differ from humans in essential physiology

90 mg: -1.02%, p=0.001), BW (45 mg: -3.51%, p=0.0019